1. 'I was convinced no one would ever understand': JC Monahan shared ...
7 apr 2021 · NBC10 Boston's JC Monahan is sharing her struggles with depression and “debilitating” anxiety. Read more on Boston.com.
NBC10 Boston’s JC Monahan is sharing her struggles with depression and “debilitating” anxiety with the hope that opening up about her experiences may help others grappling with mental health issues. In […]
2. Breaking Her Silence: JC's Personal Journey Through Depression and ...
27 sep 2023 · JC Monahan is an Emmy award winning journalist with more than 25 years of experience. She is also an AMS sealed meteorologist. In 2001 JC began ...
Check out the latest community post from one of your neighbors. (The views expressed in this post are the author’s own.)
3. JC Monahan - NBC Boston
JC Monahan is an Emmy award winning journalist with more than 25 years of experience. She is also an AMS sealed meteorologist. In 2001 JC began as a weekend ...
JC Monahan is an Emmy award winning journalist with more than 25 years of experience. She is also an AMS sealed meteorologist. In 2001 JC began as a weekend Meteorologist for WCVB-TV 5. After 10 years forecasting for the weekday EyeOpener, JC was promoted to co-anchor of Chronicle, the station’s evening magazine show, where she earned both a regional Edward…
4. The Role of Liquid–Liquid Phase Separation in Actin Polymerization
7 feb 2023 · Liquid–liquid phase separation (LLPS) has been recognized as a general cellular mechanism of control for the spatiotemporal dynamics of many ...
To date, it has been shown that the phenomenon of liquid–liquid phase separation (LLPS) underlies many seemingly completely different cellular processes. This provided a new idea of the spatiotemporal organization of the cell. The new paradigm ...
5. [PDF] Protein phase separation: a new phase in cell biology
Phase separation: Phase separation ... Monahan, Z., et al., Phosphorylation of the FUS ... Grima, J.C., et al., Mutant Huntingtin Disrupts the Nuclear Pore Complex.
6. Robust and efficient gene regulation through localized nuclear ...
5 okt 2020 · Liquid-liquid phase separation in cells is the spontaneous separation ... Monahan et al., 2019; De Wit et al., 2013 ... J. C.-G. (. 2019. ). In vivo ...
Summary: This Review examines transcriptional nuclear microenvironments in the context of embryogenesis, covering their formation, physical properties, functions in gene regulation and how they could facilitate the evolution of regulatory elements.
7. Emerging Roles for Phase Separation of RNA-Binding Proteins in Cellular ...
17 feb 2022 · ... separation (LLPS) and form fluid condensates ... separation (LLPS) (Molliex et al., 2015; Patel ... Monaghan J., Freyermuth F., Sung J. C., et al.
Liquid-liquid phase separation (LLPS) is emerging as a major principle for the mesoscale organization of proteins, RNAs, and membrane-bound organelles into biomolecular condensates. These condensates allow for rapid cellular responses to changes in metabolic ...
8. Staphylococcal Scalded Skin Syndrome (SSSS)
3 nov 2022 · ... separation of the epidermis beneath the granular cell layer. ... Wong GW, Oppenheimer SJ, Evans RM, Leung SS, Cheng JC. ... O'Connell NH, Mannix M, ...
Staphylococcal scalded skin syndrome (SSSS), also known as Ritter von Ritterschein disease (in newborns), Ritter disease, and staphylococcal epidermal necrolysis, encompasses a spectrum of superficial blistering skin disorders caused by the exfoliative toxins of some strains of Staphylococcus aureus. It is a syndrome of acute exfoliation of ...
9. [PDF] Liquid-Liquid Phase Separation by Intrinsically Disordered ... - HAL
27 feb 2021 · ... J.C.; Huang, J.R. Liquid-liquid phase separation ... Monahan, Z.; Ryan, V.H.; Janke, A.M.; Burke ... Ferreon, J.C.; Jain, A.; Choi, K.J.; Tsoi ...
10. Targeted modulation of protein liquid-liquid phase separation by ...
21 okt 2020 · Targeted modulation of protein liquid-liquid phase separation by evolution of amino-acid sequence ... Zamudio, J. C. Manteiga, E. L. Coffey, C. H. ...
Rationally and efficiently modifying the amino-acid sequence of proteins to control their ability to undergo liquid-liquid phase separation (LLPS) on demand is not only highly desirable, but can also help to elucidate which protein features are important for LLPS. Here, we propose an innovative computational method that couples a genetic algorithm to a sequence-dependent coarse-grained protein model to evolve the amino-acid sequences of phase-separating intrinsically disordered protein regions (IDRs), and purposely enhance or inhibit their capacity to phase-separate. We apply it to the phase-separating IDRs of three naturally occurring proteins, namely FUS, hnRNPA1 and LAF1, as prototypes of regions that exist in cells and undergo hom*otypic LLPS driven by different types of intermolecular interaction. We find that the evolution of amino-acid sequences towards enhanced LLPS is driven in these three cases, among other factors, by an increase in the average size of the amino acids. However, the direction of change in the molecular driving forces that enhance LLPS (such as hydrophobicity, aromaticity and charge) depends on the initial amino-acid sequence: the critical temperature can be enhanced by increasing the frequency of hydrophobic and aromatic residues, by changing the charge patterning, or by a combination of both. Finally, we show that the evolution of amino-acid sequences to modulate LLPS is strongly coupled to the composition of the medium (e.g. the presence or absence...
11. Classification of proteins inducing liquid–liquid phase separation
28 dec 2022 · J.C.. , and. Federhen. ,. S. (. 1993. ) Statistics of local complexity in amino acid sequences and sequence databases . Comput. Chem. 17. ,. 149.
Abstract. Liquid–liquid phase separation (LLPS) within the cell can form biological condensates, which are increasingly recognized to play important roles
