Table 3 from Comparative Genomics of the Major Histocompatibility Complex (MHC) of Felids | Semantic Scholar (2024)

Phylogenetic analysis revealed that MHC class I alleles were shared among different species of Scincidae with trans-species polymorphism, and did not exhibit specific genealogical inheritance, which has important implications for understanding polymorphism interspecies diversity in the MHC genes of Scincidae, and the evolution of the MHC more broadly.

It is found that intronic regions of amphibian classical MHC genes were much longer when compared with other tetrapod lineages (birds and mammals), which could partly be driven by the expansion of genome size.

The structure of the LRC is rather conservative in felids and the other Carnivora studied, but the LILR sub-region is conserved within the Felidae and has slight differences in the Canidae, but it has taken various evolutionary paths in the Mustelidae.

The de novo assembly of a cattle genome using ultra-long-read nanopore sequencing in conjunction with other advanced technologies is reported, providing a comprehensive view of the complex immune- genome.

The de novo assembly of a cattle genome is reported and the immunogenomic regions are seamlessly assembled and precisely annotated, and the MHC gene structures are integrally revealed with properly phased haplotypes.

This review summarizes data on the role of risk HLA haplotypes and a number of other candidate genes and loci, identified through genome-wide association studies, in the development of this disease and in alterations in T cell signaling.

The Felidae species, nearly all endangered and monitored for conservation concerns, have allowed a glimpse of species adaptation, mediated by MHC divergence, using comparative inferences drawn from human and mouse models.

This review compares maps of MHC gene orders in commonly studied species, where extensive sequencing has been performed, and suggests rapid evolution of M HC genes after divergence from a common ancestor.

A complex MHC structure for mammals and a relatively simpler design for nonmammalian animals with a hypothetical prototypic structure for the shark is revealed.

Comparison of the feline MHC with the murine and human MHC offers a detailed view of the consequences of genome organization in three mammalian lineages.

The role of micro-evolutionary forces, such as pathogen-mediated selection, to cause MHC variations among the two groups of Indian leopards are suggested, because theTwo groups have been bred in two different environments for a substantial period of time.

The sequence of the Mhc from human and mouse, together with a large amount of sequence and mapping information from several other species, allows us to draw general conclusions about the organization and origin of this crucial part of the immune system.

This study isolated and characterized genetic variation at the adaptively most important region of MHC class I and MHCclass II-DRB genes in 25 free-ranging African leopards from Namibia and investigated the mechanisms that generate and maintain MHC polymorphism in the species.

Fluorescence in situ hybridization analyses of selected class II PAC clones confirmed that the class II region lies in the pericentromeric region of cat chromosome B2, but apparently unlike the human and mouse MHCs, the domestic cat DRA and DRB genes have undergone multiple duplications and the DQ region has been deleted.

Results displayed a more close relationship between leopard and tiger; however, clouded leopard has a comparatively distant relationship form the other two; and MEGA neighbor joining and PAUP maximum parsimony methods were used to reconstruct phylogenetic trees among species.

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